Figure 5.

(A) POD 8 chest X-ray (1^st recipient) following allogeneic lung Tx. The arrows demonstrate areas of consolidation within the graft. (B) Pathological examination revealed infiltration of the graft with inflammatory cells and lymphocytes, suggesting pneumonia and cellular rejection. (C,D): POD 15 chest X-ray (C, 2^nd recipient) and POD 16 chest x-ray (D, 3^rd recipient) demonstrating clear aeration of the lung allografts. (E) POD 29 chest x-ray (2^nd recipient). Arrows depict caudal displacement of the left hemi-diaphragm, suggesting enlargement of the graft. Arrowheads demonstrate displacement of the trachea to the right. Consolidation was found diffusely, especially in the left upper lung, suggesting atelectasis and subsequent pneumonia. (F) Necropsy findings of the native (right) and lung graft (left). The graft enlarged more than that of native lung, especially caudally. Arrows indicate the compressed upper lobe of the graft, which enlarged toward the mediastinum. (G-K) Representative pathological findings of the native and grafted lung: (G) Bleeding, neutrophil infiltration and cellular debris were seen, indicating pneumonia. (H) Mild bronchiolitis in the lower lobe of the graft. (I) Mild pneumonia in the upper lobe of the native lung. (J) There were well-aerated regions (A) and lobular pneumonia regions (P) in the upper lobe of the graft. Evidence of pneumonia extended from the pleural region (arrow heads). (K) No evidence of cellular rejection was found in the graft.