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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Arthritis Rheumatol. 2017 Jun 2;69(7):1418–1428. doi: 10.1002/art.40104

Figure 6.

Figure 6

REDD1 is required for AMPK dependent PGC1α expression. A) Western blot analysis of AMPK phosphorylation in cultured chondrocytes isolated from Redd1+/+ and Redd1−/− mice. Right panel shows quantification. Values are mean ± SD from three different experiments. B) Western blot analysis of AMPK phosphorylation in cultured chondrocytes isolated from Redd1+/+ and Redd1−/− mice treated with AICAR or vehicle for 24 hours. Right panel shows quantification. Values are mean ± SD from three different experiments. C) qPCR analysis of Pgc1α and Tfam expression in cultured chondrocytes isolated from Redd1+/+ and Redd1−/− mice and treated with AICAR or vehicle for 24 hours. Values are mean ± SD from three different experiments. Right panel shows quantification. Values are mean ± SD from three different experiments. D) Western blot analysis of PGC1α expression in cultured chondrocytes isolated from Redd1+/+ and Redd1−/− mice and treated with AICAR or vehicle for 24 hours. Right panel shows quantification. Values are mean ± SD from three different experiments.