Table 1.
Baseline characteristics of the study subjects, overall, and by vitamin D dose allocation, in the total cohort or pre-specified subgroups*.
| Vitamin D Supplementation | Overall N=222 | Low Dose N=112 | High Dose N=110 | |
|---|---|---|---|---|
| Overall | N (%) or Mean ± SD | |||
|
| ||||
| Gender Female/Male | N | 123/99 | 60/52 | 63/47 |
| Age (years) | 71.1 ± 4.8 | 71.0 ± 4.7 | 71.2 ± 4.8 | |
| BMI (kg/m2) | 30.2 ± 4.5 | 29.7 ± 4.6 | 30.6 ± 4.4 | |
| Calcium & Vitamin D Supplement | 22 (10) | 11 (10) | 11 (10) | |
| Dietary Ca intake (mg/day) | 425 ± 292 | 453 ± 323 | 397 ± 257 | |
| Serum 25OHD (ng/ml) | 20.4 ± 7.4 | 20.0 ± 7 | 20.9 ± 8.2 | |
|
| ||||
| Sub-group by Gender | Overall | Low Dose | High Dose | |
|
| ||||
| Male | N | 99 | 52 | 47 |
|
| ||||
| Age (years) | 72.4 ± 5.5 | 72.1 ± 5.2 | 72.8 ± 5.8 | |
| BMI (kg/m2) | 28.7 ± 3.2 | 28.56 ± 3.16 | 28.89 ± 3.38 | |
| Calcium & Vitamin D Supplement | 1 (1) | 1 (1.9) | 0 (0) | |
| Dietary Ca intake (mg/day) | 413 ± 267 | 411 ± 256 | 415 ± 281 | |
| Serum 25OHD (ng/ml) | 19.5 ± 6.3 | 18.6 ± 6 | 20.4 ± 6.6 | |
|
| ||||
| Overall | Low Dose | High Dose | ||
|
| ||||
| Female | N | 123 | 60 | 63 |
|
| ||||
| Age (years) | 69.9 ± 3.7 | 69.9 ± 3.8 | 70 ± 3.6 | |
| BMI (kg/m2) | 31.5 ± 4.9 | 31.1 ± 5.3 | 31.8 ± 4.5 | |
| Calcium & Vitamin D Supplement | 21 (17.1) | 10 (16.6) | 11 (17.4) | |
| Dietary Ca intake (mg/day) | 425 ± 295 | 470 ± 342 | 384 ± 239 | |
| Serum 25OHD (ng/ml) | 21.1 ± 8.2 | 21.3 ± 7.5 | 20.9 ± 8.8 | |
|
| ||||
| Sub-group by Vitamin D-PTH cut-offs | Overall | Low Dose | High Dose | |
|
| ||||
| Vitamin D<20ng/ml and PTH>76pg/ml | N | 37 | 17 | 20 |
|
| ||||
| Age (years) | 71.2 ± 4.1 | 71.3 ± 4.2 | 71.2 ± 4.1 | |
| BMI (kg/m2) | 32.2 ± 5.2 | 31.28 ± 4.77 | 32.96 ± 5.54 | |
| Calcium & Vitamin D Supplement | 1 (2.7) | 0 (0) | 1(5) | |
| Dietary Ca intake (mg/day) | 419 ± 234.7 | 445 ± 202.4 | 397 ± 262 | |
| Serum 25OHD (ng/ml) | 14.1 ± 3.6 | 14.1 ± 3.1 | 14 ± 3.9 | |
*
There was no significant difference in any of the baseline characteristics by treatment group in the overall cohort or sub-groups.
p= independent t-test for continuous variables and chi-square for categorical variables between the two doses were not significant for any of the variables listed in the table.