Table 3.

Adverse events in all cycles for patients treated with 40 mg AR-42.

	Grade 1	Grade 2	Grade 3	Grade 4	Total
Thrombocytopenia	4	2	5		11
Neutropenia	2	5	2	1	10
Lymphopenia	1		4	1	6
Leukopenia	3	3			6
Anemia	2	2	1		5
Fatigue	2	2			4
Nausea	4				4
Taste changes	2	1			3
QTc	3				3
Diarrhea	3				3
Lung infection			1		1
Emesis		1			1
Increased ALT	1				1
Increased AST	1				1
Dizziness	1				1
Myalgia	1				1
Increased creatinine	1				1
Reflux	1				1
Rash	1				1

Patients treated with 40mg in 3 different cohorts most commonly experienced cytopenias (grade 1 – 4), fatigue, and nausea.