Table 4.
Summary of H3F3A p.K27 mutations in unilateral high‐grade gliomas identified by sequencing and/or immunohistochemistry.
| Study | Number of patients | Median age at diagnosis (range; years) | % Tumors harboring H3F3A p.K27 |
|---|---|---|---|
| Schwartzentruber et al (2012) | 6 | 10.5 (6–14) | 50% |
| Sturm et al (2012) | 8 | 11 (6–23) | 100% |
| Venneti et al (2013) | 3 | 11.6 (7–21.4) | 100% |
| Aihara et al (2014) | 18 | 42 (17–78) | 55% |
| Fontebasso et al (2014) | 11 | 11 (6–15) | 82% |
| Venneti et al (2014) | 7 | 12 (7–21) | 71% |
| Feng et al (2015)* | 15 | 31.7 (mean; 22–53) | 66.7% |
| Solomon et al (2015) † | 23 | Adults and children | 65% |
| Ryall et al (2016) | 22 | 10.9 (4–17.6) | 50% |
| Total | 113 | 65% |
*Four patients included had a grade II glioma.
†One of 15 tumors harboring an H3F3A p.K27 was a grade 2 glioma. Histologic grade was not provided for 8 tumors.