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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Arthritis Rheumatol. 2017 Jun 5;69(7):1407–1417. doi: 10.1002/art.40101

Figure 1. Treadmill exercise alleviates MIA-induced weight asymmetry and tactile hypersensitivity.

Figure 1

A. Diagram of experimental procedure to examine effects of treadmill exercise on MIA-induced tactile hypersensitivity and weight asymmetry. B. Treadmill exercise starting 10 days post-MIA injection reversed tactile hypersensitivity selectively in exercise treated rats by D35 post-MIA, corresponding to 4 weeks of exercise. *p<0.05, **p<0.01, ***p<0.001 vs BL; ##p<0.01 vs Week 1. C. Treadmill exercise starting 10 days post-MIA injection into the knee joint reversed weight asymmetry in exercise, but not sedentary rats with improvement observed by D21 post-MIA, corresponding to 2 weeks of exercise, and continued improvement D35 through D49 post-MIA. *p<0.05, **p<0.01, ***p<0.001 vs BL, #p<0.05, ##p<0.01, ###p<0.001 vs Wk 1. D. Average number of shocks per treadmill session of MIA treated rats across the first week of treadmill exercise demonstrates that rats quickly adapt to running on the treadmill. Analysis or running across the 4-week treatment, ***p<0.05 vs D11, D12, and D13. E. Average number of shocks per daily treadmill session of MIA treated rats across the 4-week treatment demonstrates that the number of shocks were only elevated the first day of the first week of treadmill training. All graphs represent mean ± SEM.