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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Arthritis Rheumatol. 2017 Jun 5;69(7):1407–1417. doi: 10.1002/art.40101

Figure 3. Treadmill exercise across 4 weeks starting 10-days post-injection increases opioid tone.

Figure 3

A. MIA-induced weight asymmetry that persisted across 35 days in sedentary rats. Exercise starting 10 days post-MIA injection blocked the MIA-induced weight asymmetry. Naloxone (3 mg/kg i.p.) re-established the weight asymmetry at 30 min post-naloxone in the exercised rats. **p<0.01 vs BL, n=6 MIA sedentary, 5 MIA exercise. B. Analysis of difference scores confirms that exercised rats demonstrate equivalent decreases in time spent in the naloxone-paired chamber whereas sedentary rats failed to show significant CPA irrespective of whether they received intra-articular saline or intra-articular MIA. *p<0.05 vs sedentary rats. All graphs represent mean ± SEM.