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. 2017 Apr 11;93(4):196–219. doi: 10.2183/pjab.93.013

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© 2017 The Japan Academy

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Role of CM polymorphism in CagA-PAR1b interaction. CagA binds to PAR1b as well as other PAR1 family members via the C-terminal CM motif. Sequence diversity within the CM motif of CagA influences the strength of CagA-PAR1b interaction. PAR1b-binding affinity of East Asian CagA possessing one CM^E motif is equivalent to Western CagA containing two CM^W motifs. Western CagA possessing four CM^W motifs, though very rare (<5% of all Western CagA), exhibits an extremely strong binding to PAR1b.