Figure 3.

Chromatin status regulated by histone acetylation. Histone acetyltransferases (HATs) are recruited by transcriptional regulators such as transcription factors and co-activators to the particular genetic loci, which form potentially active chromatin. On the other hand, histone deacetylases (HDACs) are recruited by transcriptional repressors or co-repressors and are associated with transcriptionally inactive chromatin. Specific HDAC inhibitors such as TSA and TPX A inhibit HDACs, leading to histone hyperacetylation in vivo.