Figure 6.
A unique mode of action of FK228. FK228 is activated by cellular reducing activity in cells, forming thiol groups from its intramolecular disulfide bond. One the thiols may act as a zinc-binding ligand to inhibit HDAC.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.