Table 1.
Apparent phenotypes of gene knockouts
| Genes | Phenotypes in knockout mice | Reference |
|---|---|---|
| HDAC1 | Embryonic lethality due to severe proliferation defects | 14 |
| HDAC2 | Perinatal lethality due to severe cardiac defects | 15 |
| HDAC3 | Embryonic lethality | 16 |
| HDAC4 | Death by postnatal day 10. Premature ossification of developing bones | 17 |
| HDAC5 | Cardiac deficiency | 18 |
| HDAC6 | Viable and no obvious phenotype | 19 |
| HDAC7 | Embryonic lethality due to dilatation and rupture of blood vessels | 20 |
| HDAC8 | Perinatal lethality due to skull instability | 21 |
| HDAC9 | Cardiac deficiency | 18 |
| HDAC10 | Viable | 22 |
| HDAC11 | Viable | 23 |
| SIRT1 | Mostly early postnatal lethality | 30 |
| SIRT2 | Viable | 34 |
| SIRT3 | Viable and no obvious phenotype | 35 |
| SIRT4 | Viable and no obvious phenotype | 36 |
| SIRT5 | Viable and no obvious phenotype | 35 |
| SIRT6 | Death at about 4 weeks by severe metabolic defects | 31 |
| SIRT7 | Shorter life span | 32, 33 |