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. 2017 Jun 28;7:4340. doi: 10.1038/s41598-017-04292-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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SKOV-3 cells respond to ATP by generating multiphasic ionic currents. (A) The trace shows a typical electrical response generated in SKOV-3 cells by ATP application; in cells held at −40 mV, three main components are identified in the response: 1) a fast inward current with low amplitude, 2) a robust outward current, and 3) a slow inward current. All response components were associated with an increase in membrane conductance. The bar graph shows the current density recorded for each component in a sample of 39 cells. (B) Traces show that component 2 was also activated by UTP or histamine application. All agonists were applied at 10 µM, and the bar graph summarizes the outward current density recorded in 60 cells tested for the various agonists. In general, in this and subsequent traces, responses were obtained in cells held at −40 mV, and upper bars indicate the drug application time in each case. Horizontal lines indicate zero current.