Fig. 1. Study flow chart. Group A: intensifying oral hypoglycemic agents (OHAs; sulfonylurea+metformin dose titration or fixed-dose combination added to other OHAs). Group B: basal insulin alone or added to OHA mono/combination therapy. Group C: basal bolus, premixed insulin, and continuous subcutaneous insulin infusion alone or added to OHA mono/combination therapy. HbA1c, glycosylated hemoglobin.
