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. 2017 Jun 28;7:4336. doi: 10.1038/s41598-017-04499-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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A summary of the dissociation constants (K_d) of the WT and mutants before and after addition of ligands. The bars indicate the dissociation constants, K_d. (a) Before addition of Dex, the dissociation constant (K_d) of the WT was 7.40 μM in the cytoplasm, and after addition of Dex the K_d values of the WT, C421G, A458T, and C421G-A458T were 3.00, 3.51, 6.11, and 5.84 μM, respectively, in the nucleus. K_d of the control p50-p50 in the nucleus was 2.20 μM. (b) Before addition of Dex, K_d of ∆NLS was 2.28 μM and after addition of Dex, K_d values of the ∆NLS and A458T-∆NLS mutants in the cytoplasm were 2.19 and 8.52 μM, respectively. K_d of the p50-p50 dimer in the cytoplasm was 1.77 μM. The data are presented as mean ± SD. Statistical analysis was based on ANOVA (*p < 0.05, **p < 0.01).