Table 3.
Hematological and biochemical parameters from patients with visceral leishmaniasis before and after leishmanicidal treatment initiation.
| Parameter | Unit | Pre-treatment | Day 15 | Day 30 | P-value | Post-test result |
|---|---|---|---|---|---|---|
| Hb | g/dL | 8.7 (7.6–10.0) | 9.8 (8.6–10.3) | 10.6 (9.8–11.4) | <0.0001 | *, # |
| RBC | 103/L | 3.6 (3.2–4.1) | 4.0 (3.4–4.3) | 4.1 (3.6–4.3) | 0.0005 | *, # |
| Platelets | 103/L | 167 (134–222) | 201 (172–296) | 254 (218–323) | <0.0001 | *, #, $ |
| WBC | 109/L | 2.80 (1.90–3.70) | 3.39 (2.71–4.68) | 5.70 (4.51–7.32) | <0.0001 | *, #, $ |
| Neutrophils | 109/L | 0.81 (0.58–1.18) | 1.11 (0.77–1.57) | 2.16 (1.55–3.02) | <0.0001 | *, # |
| Monocytes | 109/L | 0.37 (0.28–0.51) | 0.44 (0.33–0.59) | 0.48 (0.36–0.63) | 0.7852 | n.s. |
| Lymphocytes | 109/L | 1.45 (0.85–2.02) | 1.65 (1.22–2.39) | 2.63 (1.6–3.43) | <0.0001 | *, #, $ |
| Albumin | g/dL | 2.5 (2.2–3.0) | 2.9 (2.4–3.5) | 3.8 (3.2–4.1) | <0.0001 | *, #, $ |
| Globulin | g/dL | 4.9 (3.8–5.9) | 4.8 (4.3–6.3) | 4.5 (3.8–5.4) | 0.4081 | n.s. |
| Total protein | g/dL | 13.5 (12.4–14.9) | 12.6 (12.1–13.8) | 12.7 (12.0–13.5) | 0.0652 | n.s. |
| aPTT | g/dL | 37.1 (33.5–42.6) | 38.6 (35.7–42.4) | 37.4 (34.2–39.6) | 0.9800 | n.s. |
| AST | U/L | 58 (38–87) | 60 (46–100) | 44 (38.2–52.7) | 0.8454 | n.s. |
| ALT | U/L | 36 (26.2–70.2) | 61 (42.5–104) | 46 (32.5–56) | 0.1510 | n.s. |
| ALP | U/L | 153 (109–273) | 196 (137–320) | 211.5 (149–244.5) | 0.4374 | n.s. |
| GGT | U/L | 63.5 (20–145.5) | 103 (33.5–215) | 53.5 (26–107.8) | 0.0819 | n.s. |
| Amilase | U/dL | 45.5 (34.2–70.5) | 84 (61–152) | 70.5 (53–85.6) | 0.2207 | n.s. |
| Urea | mg/dL | 22 (16–27.2) | 22 (17–30) | 22 (17–31) | 0.3944 | n.s. |
| Creatinine | mg/dL | 0.5 (0.4–0.7) | 0.5 (0.3–0.7) | 0.5 (0.3–0.7) | 0.9758 | n.s. |
Values represent median and interquartile ranges. Log10 transformed data (which presented Gaussian distribution) were analyzed using one-way ANOVA with Tukey’s multiple comparisons post-test. Column with P-values represent the one-way ANOVA comparisons. Column with P-values represent the one-way ANOVA comparisons. P-values from post-test are represented by the following: *p < 0.05 in Pre-treatment vs. Day 15; #p < 0.05 in Pre-treatment vs. Day 30; $p < 0.05 in Day 1`s. Day 30; n.s. nonsignificant. Abbreviations: aPPT, activated partial thromboplastin time; ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, Gamma-glutamyl transpeptidase; Hb, hemoglobin; RBC, red blood cell count; WBC, white blood cell count.