Table 1. Clinical factors: baseline summary and univariate analysis.
| Clinical factors | Patient characteristics | Univariate Cox model | ||
|---|---|---|---|---|
| No. of patients | Poor prognostic group, No. of patients in each group (%) | HR | P-value | |
| Peritoneal metastases (yes vs. no) | 1,020 | 424 (41.6) | 1.617 | <0.0001 |
| ECOG PS (1 vs. 0) | 1,020 | 661 (64.8) | 1.611 | <0.0001 |
| No. of metastatic sites (≥3 vs. 0 to 2) | 1,020 | 345 (33.8) | 1.445 | <0.0001 |
| Weight loss within 3 mo (≥10% vs. <10%) | 1,018 | 154 (15.1) | 1.544 | <0.0001 |
| Time since diagnosis (<9 mo vs. ≥9 mo) | 1,020 | 524 (51.4) | 1.353 | <0.0001 |
| Presence of a primary tumor (yes vs. no) | 1,020 | 678 (66.5) | 1.360 | <0.0001 |
| Time to progression since prior therapy (<6 mo vs. ≥6 mo) | 1,016 | 645 (63.5) | 1.346 | <0.0001 |
| Tumor differentiation (poor/unknown vs. well/moderate) | 1,020 | 643 (63.0) | 1.344 | <0.0001 |
| Body weight (<60 kg vs. ≥60 kg) | 1,019 | 433 (42.5) | 1.284 | 0.0014 |
| Histologic subtype (diffuse vs. intestinal) | 1,020 | 388 (38.0) | 1.239 | 0.0119 |
| Histologic subtype (other* vs. intestinal) | 1,020 | 265 (26.0) | 1.160 | 0.1181 |
| Age group (<65 yr vs. ≥65 yr) | 1,020 | 643 (63.0) | 1.151 | 0.0613 |
| Liver metastases (yes vs. no) | 1,020 | 448 (43.9) | 1.139 | 0.0727 |
| Disease progression (during first-line therapy vs. within 4 mo after the last dose of first-line therapy) | 979 | 475 (48.5) | 1.176 | 0.0746 |
| Sex (female vs. male) | 1,020 | 300 (29.4) | 1.142 | 0.0936 |
| Ethnicity (Hispanic or Latino vs. not Hispanic or Latino) | 1,020 | 117 (11.5) | 1.251 | 0.1755 |
| Race (other† vs. Caucasian) | 1,020 | 54 (5.3) | 1.140 | 0.4453 |
| Race (Asian vs. Caucasian) | 1,020 | 287 (28.1) | 1.174 | 0.4493 |
| Measureable disease (no vs. yes) | 1,019 | 174 (17.1) | 1.042 | 0.6756 |
| Primary tumor location (GEJ vs. gastric junction) | 1,020 | 228 (22.4) | 1.023 | 0.7977 |
The factors that were included in the final model are shown in bold text. For each factor, the poor prognostic group is shown first for each group pair within parentheses.
HR = hazard ratio; ECOG = Eastern Cooperative Oncology Group; PS = performance status; GEJ = gastroesophageal junction.
*Histologic subtype (other) means mixed and unknown/missing; †Race (other) includes African-American, American Indian, or Alaska Native, multiple race, and others.