Table 1. Clinicopathological characteristics of the patients with and without a FHX of gastric cancer.
| Characteristics | FHX of gastric cancer | P | ||
|---|---|---|---|---|
| Absent (n=2,323) | Present (n=413) | |||
| Age (yr) | 60.4±11.9 | 58.1±11.9 | <0.001 | |
| Sex (Male) | 1,549 (66.7) | 291 (70.5) | 0.132 | |
| BMI (kg/m2) | 22.9±3.0 | 23.2±2.9 | 0.132 | |
| Comorbidity | 1,150 (49.5) | 207 (50.1) | 0.818 | |
| Tumor markers | ||||
| CEA (elevated) | 304 (13.1) | 58 (14.0) | 0.628 | |
| CA19-9 (elevated) | 142 (6.1) | 23 (5.6) | 0.538 | |
| Tumor location | 0.965 | |||
| Lower third | 1,356 (58.4) | 246 (59.6) | ||
| Middle third | 622 (26.8) | 109 (26.4) | ||
| Upper third | 317 (13.6) | 53 (12.8) | ||
| Entire stomach | 28 (1.2) | 5 (1.2) | ||
| Gastric resection | 0.694 | |||
| Distal gastrectomy | 1,736 (75.9) | 316 (76.5) | ||
| Total gastrectomy | 552 (23.8) | 97 (23.5) | ||
| Others | 8 (0.3) | 0 | ||
| No. of harvested LNs | 37±16 | 35±15 | 0.132 | |
| No. of metastatic LNs | 2.8±7.5 | 2.4±5.6 | 0.257 | |
| Differentiation | 0.556 | |||
| Differentiated | 998 (43.0) | 171 (41.4) | ||
| Undifferentiated | 1,325 (57.0) | 242 (58.6) | ||
| Lauren classification | 0.816 | |||
| Intestinal | 1,339 (57.6) | 246 (59.6) | ||
| Diffuse | 466 (20.1) | 82 (19.9) | ||
| Intermediate | 28 (1.2) | 3 (0.7) | ||
| Mixed | 281 (12.1) | 50 (12.1) | ||
| Undetermined | 209 (9.0) | 32 (7.7) | ||
| Macroscopic type | 0.921 | |||
| Superficial | 1,142 (49.2) | 213 (51.6) | ||
| Borrmann I | 73 (3.1) | 12 (2.9) | ||
| Borrmann II | 325 (14.0) | 54 (13.1) | ||
| Borrmann III | 683 (29.4) | 118 (28.6) | ||
| Borrmann IV | 100 (4.3) | 16 (3.9) | ||
| Lymphovascular invasion | 755 (32.5) | 148 (35.8) | 0.184 | |
| Perineural invasion | 785 (33.8) | 146 (35.4) | 0.538 | |
| Tumor size (mm) | 37±26 | 37±25 | 0.997 | |
| Tumor depth | 0.865 | |||
| pT1 | 1,299 (55.9) | 235 (56.9) | ||
| pT2 | 249 (10.7) | 39 (9.4) | ||
| pT3 | 350 (15.1) | 85 (15.7) | ||
| pT4 | 425 (18.3) | 74 (17.9) | ||
| Nodal metastasis | 0.845 | |||
| pN0 | 1,509 (65.0) | 272 (65.9) | ||
| pN1 | 269 (11.6) | 45 (10.9) | ||
| pN2 | 235 (10.1) | 47 (11.4) | ||
| pN3 | 310 (13.4) | 49 (11.9) | ||
| Distant metastasis | 171 (7.4) | 21 (5.1) | 0.095 | |
Variables are expressed as means±standard deviation or number (%).
FHX = family history; BMI = body mass index; CEA = carcinoembryonic antigen; CA19-9 = carbohydrate antigen 19-9; LN = lymph node; pT = tumor depth; pN = nodal metastasis.