Fig. 4.

Increased D2^High states in knockouts and lesions. (A) Increase in D2^High states in gene knockouts for Comt, using the dopamine/[³H]domperidone competition method (n = 4 ± SE; Table 1). (B) Increase in D2^High states in striata from adult animals that had been lesioned in the hippocampus at an early age. [³H]Raclopride saturation method; control value was 2 pmol/g (see Table 1). (C) Dopamine/[³H]raclopride competition method. (D) Dopamine/[³H]domperidone competition method. Bars indicate SE (n = 3; Table 1).