Table 2.
Expression of pro-inflammatory chemokines and receptors in BAP1-positive and BAP1-negative UM (a), and in disomy 3/BAP1-positive tumors, with and without 8q gain (b) in the Leiden cohort
| (a) | BAP1-positive (n = 24) | BAP1-negative (n = 30) | P value+ |
|---|---|---|---|
| CCL3 (MIP-1α) | 6.7 (6.5–8.5) | 6.7 (6.3–8.0) | 0.321 |
| VEGFA probe 1 | 6.8 (6.5–7.4) | 6.8 (6.5–7.3) | 0.651 |
| VEFGA probe 2 | 6.4 (6.3–6.8) | 6.4 (6.2–6.8) | 0.403 |
| CXCL12 (SDF-1) probe 1 | 7.1 (6.6–8.6) | 7.3 (6.5–9.4) | 0.689 |
| CXCL12 (SDF-1) probe 2 | 6.6 (6.3–7.1) | 6.6 (6.3–7.6) | 0.175 |
| CXCL12 (SDF-1) probe 3 | 6.5 (6.2–7.1) | 6.5 (6.0–7.3) | 0.848 |
| CCL7 | 6.2 (6.0–6.5) | 6.3 (5.9–6.7) | 0.088 |
| CSF-1 | 6.4 (6.3–6.7) | 6.5 (6.3–6.7) | 0.130 |
| CCL2 (MCP-1) | 7.2 (6.4–9.5) | 7.1 (6.4–9.1) | 0.614 |
| CCL5 (RANTES) probe 1 | 6.9 (6.4–10.7) | 7.5 (6.5–12.1) | <0.001 |
| CCL5 (RANTES) probe 2 | 7.7 (6.6–12.4) | 8.8 (7.0–14.4) | 0.005 |
| CXCL10 (IP-10) | 6.8 (6.4–10.5) | 7.4 (6.4–10.4) | 0.065 |
| CCR7 | 6.4 (6.1–7.0) | 6.3 (6.0–7.2) | 0.903 |
| CXCR4 probe 1 | 6.5 (6.2–7.2) | 6.7 (6.2–8.3) | 0.038 |
| CXCR4 probe 2 | 6.5 (6.1–6.9) | 6.4 (6.2–6.8) | 0.010 |
| CXCR4 probe 3 | 6.6 (6.2–7.5) | 6.8 (6.2–8.2) | 0.216 |
| (b) | D3/BAP1+/n8q (n = 9) | D3/BAP1+/8q gain (n = 8) | P value* |
|---|---|---|---|
| CCL3 (MIP-1α) | 6.6 (6.5–6.8) | 6.8 (6.7–8.1) | 0.002 |
| VEGFA probe 1 | 6.7 (6.5–6.9) | 6.9 (6.6–7.4) | 0.059 |
| VEFGA probe 2 | 6.4 (6.3–6.6) | 6.5 (6.3–6.8) | 0.236 |
| CXCL12 (SDF-1) probe 1 | 7.1 (6.7–7.9) | 7.1 (6.6–8.6) | 0.743 |
| CXCL12 (SDF-1) probe 2 | 6.5 (6.3–6.8) | 6.5 (6.4–6.8) | 0.743 |
| CXCL12 (SDF-1) probe 3 | 6.5 (6.3–6.7) | 6.5 (6.2–7.0) | 0.888 |
| CCL7 | 6.1 (6.0–6.3) | 6.3 (6.1–6.4) | 0.277 |
| CSF-1 | 6.4 (6.3–6.6) | 6.4 (6.3–6.6) | 0.606 |
| CCL2 (MCP-1) | 6.8 (6.4–7.7) | 7.3 (6.8–9.1) | 0.059 |
| CCL5 (RANTES) probe 1 | 6.8 (6.4–7.0) | 6.9 (6.5–7.5) | 0.236 |
| CCL5 (RANTES) probe 2 | 7.4 (6.6–8.2) | 7.9 (7.0–8.9) | 0.277 |
| CXCL10 (IP-10) | 6.7 (6.4–7.4) | 6.8 (6.5–8.4) | 0.321 |
| CCR7 | 6.3 (6.1–6.6) | 6.4 (6.2–6.7) | 0.606 |
| CXCR4 probe 1 | 6.4 (6.2–6.7) | 6.5 (6.3–6.9) | 0.114 |
| CXCR4 probe 2 | 6.5 (6.1–6.6) | 6.5 (6.2–6.9) | 0.370 |
| CXCR4 probe 3 | 6.5 (6.2–6.9) | 6.6 (6.3–7.3) | 0.321 |
The boldface indicates a significant difference
D3 disomy 3, BAP1+ positive BAP1 protein expression, n8q normal chromosome 8q status, 8q gain chromosome 8q gain, n number of patients; median (range)
+ P value comparison of chemokine expression in BAP1-positive and BAP1-negative tumors
*P value comparison of chemokine expression in tumors with D3/BAP1+/n8q and tumors with D3/BAP1+/8q gain