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. 2017 Jun 29;8:730. doi: 10.3389/fimmu.2017.00730

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Copyright © 2017 Wang, Elsheikha, Zhu, Chen, Li, Yue, Zhang, Huang and Zhu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunization with ΔGRA17 promotes survival and inhibits brain cyst burden after infection. (A) Survival curves following challenge of ΔGRA17-immunized mice with 20 cysts of Toxoplasma gondii type II Pru strain, compared with mock-immunized mice, 70 days after immunization. The survival of mice was monitored for 35 days. A Log-rank (Mantel–Cox) test demonstrated a significant difference between the immunized and control groups (P = 0.0001). (B) Cyst burden in the brain of mice that survived to 35 days after challenge (ΔGRA17-immunized mice vs infected, non-immunized mice). Data points indicate means ± SD.