| a. between non-neoplastic and neoplastic region | ||||||||
|---|---|---|---|---|---|---|---|---|
| Non-neoplastic region | Neoplastic region | |||||||
| n | mean | ±sd | n | mean | ±sd | p value | ||
| Methylation status of MUC4 promoter | ||||||||
| 5mC | (31) | 63.82 | ±25.01 | (31) | 65.18 | ±29.64 | 0.846 | |
| 5hmC | (33) | 18.64 | ±17.65 | (33) | 31.77 | ±33.05 | 0.019 | * |
| Expression level of mRNA | ||||||||
| MUC4 | (33) | 2.20 | ±0.75 | (33) | 2.44 | ±0.89 | 0.226 | |
| TET1 | (33) | 1.85 | ±0.44 | (33) | 1.92 | ±0.63 | 0.602 | |
| TET2 | (31) | 0.27 | ±0.70 | (31) | 0.29 | ±0.57 | 0.910 | |
| TET3 | (32) | 2.60 | ±0.72 | (32) | 2.56 | ±0.79 | 0.867 | |
| AICDA | (33) | 2.34 | ±0.55 | (33) | 2.30 | ±0.64 | 0.792 | |
| GCM1 | (33) | 1.65 | ±0.42 | (33) | 1.61 | ±0.65 | 0.730 | ** |
| Dnmt1 | (32) | −0.02 | ±0.53 | (32) | 0.03 | ±0.58 | 0.742 | |
| Dnmt3a | (32) | 0.05 | ±0.39 | (32) | 0.04 | ±0.47 | 0.872 | |
*Willcoxon T test, **unequal T test.