Table 4.
Adjusted pooled hazard ratios (pHRs) and 95% confidence intervals (CIs) for the association between cigarette smoking status at diagnosis and overall survival among 9,114 women from 19 studies diagnosed with epithelial ovarian cancer, overall and for serous ovarian tumors, stratified by stage
| Overall
|
Serous
|
p values | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Localized stage
|
Advanced stage1
|
Localized stage
|
Advanced stage1
|
|||||||||||
| Cases | pHR2 | 95% CI | Cases | pHR2 | 95% CI | p values | Cases | pHR2 | 95% CI | Cases | pHR2 | 95% CI | ||
| Smoking status | ||||||||||||||
|
| ||||||||||||||
| Never | 952 | 1.00 | Ref. | 4,014 | 1.00 | Ref. | 182 | 1.00 | Ref. | 2,705 | 1.00 | Ref. | ||
|
| ||||||||||||||
| Former | 529 | 1.32 | (0.96–1.82) | 2,371 | 1.07 | (1.00–1.15) | 0.21 | 134 | 1.46 | (0.87–2.45) | 1,689 | 1.09 | (1.01–1.17) | 0.27 |
|
| ||||||||||||||
| Current | 284 | 1.63 | (1.19–2.22) | 964 | 1.16 | (1.06–1.28) | 0.04 | 56 | 1.67 | (0.84–3.34) | 665 | 1.09 | (0.98–1.21) | 0.23 |
1
Advanced stage includes regional and distant stage.
2
Adjusted for age (continuous), race/ethnicity (non-Hispanic White, Hispanic White, Black, Asian or other) and grade (well differentiated, moderately differentiated, poorly differentiated or undifferentiated).