FIG 1 .

Henipavirus replication and tropism in human olfactory cultures. The kinetics of HeV (black dashed line), NiV-B (gray dashed line), and NiV-M (black solid line) replication in cultures of hOE infected at a low MOI of 0.01 (A) or a high MOI of 1 (B). Results are expressed as averages of 3 repetitions in hOE from 2 different donors; error bars represent standard errors of the means. (C) Cytopathic effect in control or HeV-, NiV-B-, or NiV-M-infected hOE cultures on day 5 p.i. (D) Representative panel of hOE cultures stained for immunofluorescent detection of OMP (green), NiV-M glycoprotein (red), and nucleus (4′,6-diamidino-2-phenylindole [DAPI], blue). In orange are hOE positive for both OMP and viral antigen. Bar, 25 µm.