Table 2. Histological scoring of colonic inflammation in HLA-B27 transgenic rats dosed orally for 8 days with vehicle or WAY-169916 (0.5, 0.15, or 0.05 mg/kg).
| Group | Ulceration (0-2) | Inflammatory infiltrating cells (0-3) | Lesion depth (0-3) | Fibrosis (0-2) | Total inflammation score (0-10) |
|---|---|---|---|---|---|
| Vehicle | 2.00 ± 0 | 3.00 ± 0 | 1.50 ± 0 | 1.31 ± 0.13 | 7.81 ± 0.13 |
| Rat no. 1 | 2 | 3 | 1.5 | 1.25 | 7.75 |
| Rat no. 2 | 2 | 3 | 1.5 | 1.5 | 8 |
| Rat no. 3 | 2 | 3 | 1.5 | 1.25 | 7.75 |
| Rat no. 4 | 2 | 3 | 1.5 | 1.25 | 7.75 |
| WAY-169916 (0.5 mg/kg) | 0.69 ± 0.24* | 0.50 ± 0.20* | 0.69 ± 0.22* | 0.69 ± 0.24* | 2.56 ± 0.55* |
| Rat no. 1 | 0.75 | 0.50 | 0.75 | 0.75 | 2.75 |
| Rat no. 2 | 1 | 0.25 | 1 | 1 | 3.25 |
| Rat no. 3 | 0.5 | 0.75 | 0.5 | 0.5 | 2.25 |
| Rat no. 4 | 0.5 | 0.50 | 0.5 | 0.5 | 2 |
| WAY-169916 (0.15 mg/kg) | 0.60 ± 0.82* | 1.00 ± 0.58* | 0.40 ± 0.55* | 0.10 ± 0.22* | 2.00 ± 2.0* |
| Rat no. 1 | 1.5 | 1.5 | 1 | 0.5 | 4.5 |
| Rat no. 2 | 1.5 | 1.5 | 1 | 0 | 4 |
| Rat no. 3 | 0 | 0.5 | 0 | 0 | 0.5 |
| Rat no. 4 | 0 | 0.5 | 0 | 0 | 0.5 |
| WAY-169916 (0.05 mg/kg) | 0.88 ± 1.03* | 1.75 ± 1.17* | 0.50 ± 0.58* | 0.63 ± 0.75* | 3.75 ± 3.50* |
| Rat no. 1 | 0 | 0.50 | 0 | 0 | 0.5 |
| Rat no. 2 | 1.5 | 2.75 | 1 | 1.5 | 6.75 |
| Rat no. 3 | 2 | 2.75 | 1 | 1.5 | 7.25 |
| Rat no. 4 | 0 | 1.00 | 0 | 0 | 1 |
Means ± SD and individual rat scores below the mean are shown.
*
Significantly less than vehicle