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. 2017 Jun 29;8:446. doi: 10.3389/fphys.2017.00446

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Copyright © 2017 Zhang, Tu, Wang, Hu, Li, Cheng, Yin, Li and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of resveratrol on SIRT1 expression in nucleus depleted by Pb exposure. (A–E) Representative Western blot and quantitative results for SIRT1 level in nucleus and cytosol of hippocampus. The densities are normalized to β-actin, β-Tubulin or Lamin B respectively. (F) The endogenous Sirt1 transcript levels were determined by RT-qPCR from mice hippocampal homogenates of each group. Quantitative results for each sample normalized by GADPH. Values are expressed as mean ± SEM (n = 6). (G) Localization of SIRT1 in CA1 region of mice hippocampus observed under fluorescence microscope. SIRT1 is shown in green, DAPI staining in blue. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001 compared to Cont group; ^#P < 0.05 compared to Pb group.