Table 2. Expression levels of LncHIFCAR and HIF-1α target genes in normal versus cancer obtained from the Oncomine microarray data sets.
|
Expression fold change |
||||
|---|---|---|---|---|
| RNA | Peng head–neck oral cavity SCC (57) versus normal (22) | Zhao breast invasive ductal breast carcinoma (40) versus normal (3) | TCGA colorectal colon adenocarcinoma (101) versus normal (19) | TCGA colorectal rectal adenocarcinoma (60) versus normal (19) |
| LncHIFCAR | 4.484*** | 1.693** | 1.916*** | 1.762*** |
| LOXL2 | 1.977*** | 1.866*** | 2.437*** | 2.33*** |
| PGK1 | 1.362*** | 1.889*** | 1.982*** | 2.216*** |
| VEGFA | 1.164* | 2.598*** | 1.054*** | 1.095*** |
| GLUT1 | 1.135* | 2.8*** | 2.017*** | 2.282*** |
| LDHA | 1.414*** | 1.467** | 1.176* | NS |
| HIF1A | 1.188* | NS | NS | NS |
| CITED2 | NS | NS | NS | NS |
HIF-1α, hypoxia-inducible factor-1α; NS, no statistically significant difference (t-test, P>0.05); SCC, squamous cell carcinoma.
Statistically significant (t-test, *P<0.05, **P<0.01 and ***P<0.001).