Table 1.
Effects of ginsenoside Rk3 and Rh4 (KG-KH) on body weight, kidney weight, kidney index, blood urea nitrogen (BUN), and creatinine in cisplatin-injected rats
| Body weight (g) | Kidney weight (g) | Kidney index1) | BUN (mg/dL) | Creatinine (mg/dL) | |
|---|---|---|---|---|---|
| Normal | 257.3 ± 9.0 | 2.00 ± 0.20 | 0.78 ± 0.08 | 9.48 ± 3.08 | 0.78 ± 0.21 |
| CP 2) | 211.2 ± 7.3# | 2.59 ± 0.13# | 1.23 ± 0.07# | 47.07 ± 6.76# | 2.67 ± 0.55# |
| CP + KG-KH (2 mg/kg) | 219.3 ± 13.9 | 2.39 ± 0.09** | 1.09 ± 0.04** | 38.63 ± 4.51* | 1.95 ± 0.36* |
| CP + KG-KH (6 mg/kg) | 215.7 ± 17.1 | 2.29 ± 0.07** | 1.07 ± 0.1** | 33.60 ± 4.68** | 1.80 ± 0.35** |
Data are presented as mean ± standard deviations (n = 6).
1)
Kidney index represents % ratio of kidney weight to body weight.
2)
CP indicates cisplatin (5.0 mg/kg, i.p.). Statistically significant differences were determined by t test (#p < 0.01 compared with normal group) or ANOVA (*p < 0.05; **p < 0.01 compared with CP control group).