Figure 5.

HOTAIR promotes thyroid cancer cell growth and invasion through inhibition of miRNA-1. A. The expression level of miR-1 was measured by qRT-PCR in TPC-1 and FTC-133 cells transfected with si-HOTAIR3# and anti-miR-1, si-HOTAIR3# and anti-NC, and control and anti-NC. B and C. Proliferation was detected by MTT assay in treated TPC-1 and FTC-133 cells. D, E. Proliferation was detected by colony-forming unit assay in treated TPC-1 and FTC-133 cells. F. The effect of HOTAIR on thyroid cancer cell invasion through miRNA-1 by Transwell assays (*P < 0.05).