Table 2.

Dicer alteration in drug-resistant cancers

Dicer alteration trend	Performed assay	Drug resistance	Cancer	Experimental condition	References
↑	Western blot; Quantitative reverse transcriptase PCR	Gefitinib	Lung cancer	Cell culture and human biopsy	[125]
↓	Western blot; Quantitative reverse transcriptase PCR	Cisplatin	Ovarian cancer	Cell culture	[126]
↓	Immunohistochemical analysis	5-Fluorouracil	Oral squamous carcinoma	Human biopsy	[127]
↓	Western blot	Doxorubicin	Breast cancer	Cell culture	[128]
↓	Immunoblot analysis; Quantitative reverse transcriptase PCR	Tamoxifen	Breast cancer	Cell culture	[129]
↓	siRNA silencing	Cisplatin	Breast cancer	Cell culture	[130]
↓	siRNA silencing	Temozolomide	Glioblastoma	Cell culture	[131]
↓	Western blot	Cisplatin	Cervical cancer	Cell culture	[132]
↑*	Gel mobility-shift assay	Amphiphilic peptide LK-L1C/K6W/L8C	Cervical and breast cancer	Recombinant human Dicer	[133]

^*Functional analysis of Dicer activity.