Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Activation of the Hypoxia Inducible Factor (HIF) pathway in response to hypoxia. HIF-α levels are controlled in normoxia by PHD-mediated hydroxylation (OH) and recognition by the E3-ligase complex containing the tumour suppressor pVHL. In hypoxia, Prolyl Hydroxylases (PHDs) and FIH are inhibited and HIF-α escapes VHL-dependent degradation. T-bars represent repression.
