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. 2017 May 20;5(2):25. doi: 10.3390/biomedicines5020025

Figure 7.

Figure 7

MEK-ERK signaling is a prerequisite for the promotion of cell cycle re-entry of RPE cells mediated by β-catenin signaling. (A) Schematic showing an experimental paradigm; (B) Effect of U0126 on cell cycle re-entry of RPE cells that was promoted by EGTA treatment (11 newts). The left hand graph shows the proportion of BrdU+ cells in the Center of the RPE on day 10, and the right hand graph shows the relative changes in the presence of U0126. The value was significantly lower (Sheffe’s pairwise comparison test following the Friedman test, P = 0.0009) in the presence of U0126; (C) Effect of U0126 on nuclear translocation of β-catenin in RPE cells that was promoted by EGTA treatment (4 newts). The left hand graph shows the proportion of β-catenin+ nuclei in the Center of the RPE on day 5, and the right hand graph shows the relative changes in the presence of U0126. The value decreased significantly (Sheffe’s pairwise comparison test following the Friedman test, P = 0.0455) in the presence of U0126.