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. 2017 Jun 14;5(2):30. doi: 10.3390/biomedicines5020030

Figure 1.

Figure 1

Schematic representation of the extrinsic and intrinsic apoptotic pathway in T-lymphocytes. Arrows indicate activation, red and black T bars indicate inhibition. CASP: caspase; BID: BH3-interacting-domain death agonist; BAX: BCL-2-associated X protein; BCL-2: B cell lymphoma 2; XIAP: X-linked inhibitor of apoptosis protein; CYT-C: cytochrome C; APAF-1: apoptotic protease-activating factor 1; SMAC: second mitochondria-derived activator of caspases.