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. 2017 Jun 21;5(2):33. doi: 10.3390/biomedicines5020033

Figure 2.

Figure 2

T-cell manipulation strategies to control GVHD and improve post-haematopoietic stem cell transplantation (HSCT) immune reconstitution. Ex vivo T-cell depletion techniques have evolved and currently include CD3/CD19 depletion, TCR-αβ/CD19 depletion, and infusion of CD45RA-depleted grafts [14,15,16]. To boost immune reconstitution after T-cell depleted haploidentical HSCT, genetically modified T cells and pathogen-specific T cells are increasingly used in the clinic [17,18]. Treg = regulatory T cell; GVL = graft-versus-leukaemia; mTOR = mechanistic target of rapamycin; NOTCH = neurogenic locus notch homolog protein; JAK-STAT = Janus kinase/signal transducer and activator of transcription.