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Egr2Lo/Lo mice have a variably expressed hindbrain segmentation defect. (A) P14 mice homozygous for the hypomorphic allele, Egr2Lo/Lo, were runted and displayed severe trembling. (B–D) In contrast to wild-type E10.5 embryos (B), Egr2Lo/Lo embryos showed a range of hindbrain segmentation defects that include fusion of cranial nerves V with VII and VIII (C, arrow) or fusion of cranial nerves IX and X (D, arrow).
