Figure 3.

Extracellular matrix deposition and WISP-1 expression in kidney tissues from patients with MCD, IgAN, DN and FSGS and the negative controls. Representative images of histological and immunohistochemical staining images. Renal fibrosis indices and WISP-1 levels are increased in renal biopsy tissues from patients with fibrotic diseased diseases (IgAN, DN, and FSGS) compared with patients with MCD (minimal positive control) and negative controls. DN, diabetic nephropathy; FSGS, focal segmental glomerulosclerosis; IgAN, IgA nephropathy; MCD, minimal change disease; negative control, normal kidney tissues from patients with renal cell carcinoma; PAS, periodic acid-Schiff. Bars =50 μm.