Table 3.
Effect of ethanolic extract of Vernonia amygdalina (VA) on serum alanine transferase (ALT) activity.
| Group | Dose (mg/kg bw) | ALT (U/L) | |||||
|---|---|---|---|---|---|---|---|
| D0 | D7 | D14 | D21 | D28 | D35 | ||
| Control (+) | 0 | 43.47 ± 16.24 | 61.63 ± 17.16 x | 80.00 ± 9.09 z | 79.57 ± 8.46 z | 82.14 ± 6.64 z | 84.00 ± 5.29 z |
| VA extract | 50 | 39.17 ± 10.04 | 58.14 ± 9.58 z | 56.75 ± 10.63 c,z | 51.37 ± 3.58 c,z | 50.13 ± 5.79 c,y | 49.50 ± 4.81 c,x |
| 100 | 44.93 ± 15.01 | 63.01 ± 3.01 z | 55.75 ± 4.65 c,x | 54.00 ± 5.47 c | 49.00 ± 4.24 c | 47.37 ± 4.89 c | |
| Reference (silymarin) | 54 | 42.56 ± 12.22 | 54.56 ± 7.88 y | 49.42 ± 3.10 c | 50.42 ± 6.39 c | 48.86 ± 4.74 c | 46.57 ± 5.80 c |
Values are expressed as mean ± standard deviation (SD). n = 5; Data was analyzed by students t-test, where a = p < 0.1, b = p < 0.05, c = p < 0.01 compared to induced control (+) group; x = p < 0.1, y = p < 0.05, z = p < 0.01 compared to D0.