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. 2017 Jun 23;8:15879. doi: 10.1038/ncomms15879

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Copyright © 2017, The Author(s)

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) Time lapse IOS images showing the primary somatosensory cortical response (darkened area) to stimulation of the contralateral forepaw (100 Hz for 1 s). Red circle denotes infarct area. Grey levels in each image reflect percent changes in light reflectance averaged over 0.5–1.5 s after forelimb stimulation relative to BL. (b) Graph plotting the area of cortical territory activated by forelimb stimulation in sham stroke controls (Control stimulation: n=5 mice; ChR2 stimulation: n=7 mice) or mice with stroke that received control or optogenetic stimulated mice (Control stimulation: n=11 mice; ChR2 stimulation: n=10 mice). (c) Graph plotting peak cortical responses (absolute value of %ΔR/R) to forelimb stimulation. Data are means±s.e.m. ^#P<0.05, ^##P<0.01, ^###P<0.001 based on t-tests comparing post-stroke time points in each group designated by colour to respective BL values. *P<0.05, **P<0.01, ***P<0.001 based on t-tests comparing stroke+stimulation versus stroke+control stimulation. Scale bar, (a) 1 mm.