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. Author manuscript; available in PMC: 2017 Jun 29.
Published in final edited form as: Mech Ageing Dev. 2016 Mar 21;161(Pt A):19–36. doi: 10.1016/j.mad.2016.03.007

Fig. 2.

Fig. 2

Down-regulation of components of the SAC and centromere proteins is observed during aging. A trend for reduced expression levels of ploidy-related genes occurs in old mice (16or24-months-old) relative to young (1 month-old) in tissues known to accumulate ploidy changes with age. Female mice (A) lung, (C) heart, (E) brain and (G) kidney. Male mice(B) lung, (D) heart, (F) brain and (H) kidney. Asterisks represent statistically significant differences (p<0.05). Data was plotted from (Zahn et al., 2007).