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Aneuploidy assessed by four-color interphase FISH in E13.5 embryonic cerebral cortex of WT animals. Interphase FISH is a quantitative and sensitive approach for the analysis of ploidy at the single-cell level, irrespective of the proliferating status of the tested tissue. Examples of diploid and aneuploid cells are highlighted by the dotted line. Ploidy is shown as assigned by the colors of the fluorophores used to label FISH probes.
