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. Author manuscript; available in PMC: 2017 Jun 29.
Published in final edited form as: J Am Chem Soc. 2015 Mar 4;137(10):3486–3489. doi: 10.1021/jacs.5b00670

Scheme 1.

Scheme 1

Pre-hybridization of Spherical Nucleic Acid–Gold Nanoparticle Conjugates with n Strongly Bound Oligonucleotides (Blue) To Allow Independent Measurement of the Binding Constant of the n+1 Strand (Yellow)