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Effects of C2-ceramide, PACAP, or both on Tau distribution in cerebellar granule cells. Shown is visualization by immunohistochemistry of Tau in control conditions (A) and in granule cells treated with 20 μM C2-ceramide (B), 10-7 M PACAP (C), or C2-ceramide plus PACAP (D). Arrows show the dotted distribution of Tau along neuritic processes. Scale bar, 10 μm.
