Fig. 6.

RERG suppressed MMPs and pro-angiogenic factors through inhibition of NF-κB signaling. a IHC analyses or immunofluorescence analyses of the expression of NF-κB (p65 and p-p65), IL8, IL6, TIMP-2, MMP-2, and MMP-9 in tumors from nude mice. Nuclei were counterstained by DAPI (blue) in the merged pictures of immunofluorescence analyses. Original magnification is × 200 inner enlarged magnification is × 400. Bar represents 50 μm and 20 μm, respectively. b IHC scores of NF-κB (p65 and p-p65), IL8, IL6, TIMP-2, MMP-2, and MMP-9 in tumors from nude mice. **: P < 0.01, ***: P < 0.001 by Mann-Whitney U test. c Schematic diagram for the molecular basis of RERG as a tumor suppressor gene in NPC, based on decreasing cell proliferation and inhibiting migration, invasion and angiogenesis through the ERK/NF-κB signaling pathway