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. 2017 Jun 29;8:302. doi: 10.3389/fneur.2017.00302

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Copyright © 2017 Tilikete and Desestret.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pathological features of degenerative inferior olive hypertrophy. Hypertrophic inferior olive (A) compared to contralateral side (B) (Bodian Luxol, X200). Note the mild demyelination of the surrounding white matter. (C) Coronal section of the medulla oblongata showing hypertrophy of the left inferior olive (Loyez stain). (D) Swelled and vacuolated nerve cells (“fenestrated neurons”) observed in the hypertrophic inferior olive [from (A), Bodian Luxol, X400]. Courtesy of Charles Duyckaerts and Franck Bielle, Escourolle’s Lab, Pitie-Salpetriere Hospital, Paris, France. Adapted from Ref. (51).