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. 2017 Jun 26;8:15475. doi: 10.1038/ncomms15475

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Exploration of the role of sex in modifying the genotype effect in studies of continuous traits of knockout mice data from the IMPC. (a) Distribution of sex effect in the genotype significant data sets when using a 1% FDR. Overall, 110,586 data sets were tested and 3.4% (3,719) were significant for the stage 1 genotype effect. Of these, 12% (n=466) were classed as SD. (b) Distribution of sex effect in the genotype significant data sets when processing only multi-batch data sets at a 5% FDR. A total of 46,925 data sets were tested and 8.9% (3,719) were significant for the stage 1 genotype effect. Of these, 13.8% (n=575) were classed as SD.