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. 2017 Jul;362(1):131–145. doi: 10.1124/jpet.117.240721

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Fig. 7. — Identification of retinal Schiff base conjugates in Abca4^–/–Rdh8^–/– mice treated with MB-005 and MB-006. Following drug administration, mice (1–2 months of age) were exposed to intense light for 10 minutes. After a 30-minute recovery under darkness, animals were sacrificed and retinoids were extracted from the eyes. (A and B) Shown in the left panels are selective ion chromatograms for MB-005–retinal conjugates (MB-005-Ret) (at m/z = 572.6) (A) and MB-006–retinal conjugates (MB-006-Ret) (at m/z = 588.6) (B). Panels on the right show the mass spectra of the peaks coinciding with the retention times of their authentic standards. Insets display the tandem mass spectrometry fragmentation patterns of the two imines, which were identical to their corresponding standards.