Table 2.

Regimens and doses of chemotherapy

Adjuvant setting
Regimen	Drug	Dose	Frequency
Capecitabine	Capecitabine	2000 mg/m2 p.o. daily for 14 days	Every 3 weeks*
5-FU	5-FU Calcium folinate	400 mg/m2 i.v. Infusion 46 h: 2400 mg/ m2 i.v. 400 mg/m2 i.v.	Every 2 weeks**
Capeox	Capecitabine Oxaliplatin	2000 mg/m2 p.o. daily for 14 days 130 mg/m2 i.v.	Every 3 weeks*
Folfox	5-FU Calcium folinate Oxaliplatin	400 mg/m2 i.v. Infusion 46 h: 2400 mg/ m2 i.v. 400 mg/m2 i.v. 85 mg/m2 i.v.	Every 2 weeks**
Metastatic setting
Regimens	Drug	Dose	Frequency
Capecitabine	Capecitabine	2000 mg/m2 p.o. daily for 14 days	Every 3 weeks*
5-FU	5-FU Calcium folinate	400 mg/m2 i.v. Infusion 46 h: 2400 mg/ m2 i.v. 400 mg/m2 i.v.	Every 2 weeks**
Capeox	Capecitabine Oxaliplatin	2000 mg/m2 p.o. daily for 14 days 130 mg/m2 i.v.	Every 3 weeks*
Folfox	5-FU Calcium folinate Oxaliplatin	400 mg/m2 i.v. Infusion 46 h: 2400 mg/ m2 i.v. 400 mg/m2 i.v. 85 mg/m2 i.v.	Every 2 weeks***
Irinotecan	Irinotecan	200 mg/m2 i.v.	Every 2 weeks****
Capiri	Capecitabine Irinotecan	1600 mg/m2 p.o. daily for 14 days 200 mg/m2 i.v.	Every 3 weeks *
Folfiri	5-FU Calcium folinate Irinotecan	400 mg/m2 i.v. Infusion 46 h: 2400 mg/ m2 i.v. 400 mg/m2 i.v. 180 mg/m2 i.v.	Every 2 weeks****
Irox	Irinotecan Oxaliplatin	165 mg/m2 i.v. 85 mg/m2 i.v.	Every 2 weeks****

*maximum 8 series

**maximum 12 series

i.v. intravenous, p.o. per os

*optional addition of bevacizumab 7.5 mg/m² i.v

**optional addition of bevacizumab 5 mg/m² i.v

***optional addition of bevacizumab 5 mg/m² i.v., irinotecan 165 mg/m² i.v., cetuximab 500 mg/m² i.v., or panitumumab 6 mg/kg i.v

****optional addition of bevacizumab 5 mg/m² i.v., cetuximab 500 mg/m² i.v., or panitumumab 6 mg/kg i.v