Table 1. Description of infections where protective or pathologic roles of IL-17 have been demonstrated.
Protective roles of IL-17 | Pathologic role of IL-17 | |
---|---|---|
Extracellular bacteria |
Klebsiella pneumoniae
48, Citrobacter rodentium
49, Staphylococcus aureus 50, and Bordetella pertussis 51 |
Bordetella pertussis
56, 69, Porphyromonas gingivalis 66, and Haemophilus influenza 70 |
Intracellular bacteria |
Listeria monocytogenes
71, Mycoplasma pulmonis
72, Legionella pneumophila 73, 74, Salmonella typhimurium 75, Chlamydia muridarum 76, Francisella tularensis 77, and Mycobacterium tuberculosis 78 |
Mycobacterium tuberculosis 96– 98 |
Parasites |
Trypanosoma cruzi
104, Toxoplasma gondii
105, Leishmania braziliensis 106, and Echinococcus granulosus 107 |
Leishmania major
112, 113, Leishmania guyanensis 114, Eimeria tenella 115, and Toxoplasma gondii 116 |
Fungus |
Candida albicans
117, Cryptococcus neoformans
118, Pneumocystis carinii 119, and Aspergillus fumigatus 120 |
Candida albicans
130– 133 and Aspergillus fumigatus 133 |
Virus | H5N1 134– 136 and HIV 154, 155 | H1N1 137– 139, respiratory syncytial virus 144– 146, herpes simplex virus 147, 148, Epstein-Barr virus 149, 150, vaccinia virus 142, 143, Dengue virus 153, hepatitis B and C virus 140, 141, and HIV 159 |
HIV, human immunodeficiency virus; IL-17, interleukin-17.