Table 1.
Patient and tumor characteristics of BRCA1 and BRCA2 mutation carriers
| Number of BRCA1 carriers (%) | Number of BRCA2 carriers (%) | Total | |
|---|---|---|---|
|
| |||
| Histology | |||
| Invasive ductal carcinoma | 203 (81) | 160 (65) | 363 |
| Invasive lobular carcinoma | 2 (0.8) | 18 (7.3) | 20 |
| Mixed invasive ductal and lobular carcinoma | 9 (3.6) | 20 (8.1) | 29 |
| Other | 13 (5.2) | 12 (4.9) | 25 |
| Unknown | 2 (0.8) | 1 (0.4) | 3 |
| Invasive carcinoma + DCISa | 132 (53) | 150 (61) | 282 |
| Pure DCIS | 21 (8.4) | 35 (14) | 56 |
| Total | 250 | 246 | 496 |
|
| |||
| Invasive Carcinoma | |||
| Tumor receptor status | |||
| luminal | 92 (40) | 176 (83) | 268 |
| basal | 128 (56) | 26 (12) | 154 |
| ER/PR neg Her2pos | 3 (1.3) | 5 (2.4) | 8 |
| Unknown | 6 (2.6) | 4 (1.9) | 10 |
| Total | 229 | 211 | 440 |
|
| |||
| Nuclear Grade | |||
| 1 | 2 (0.8) | 8 (3.3) | 10 |
| 2 | 63 (25) | 102 (42) | 165 |
| 3 | 160 (64) | 105 (43) | 265 |
| Unknown | 24 (9.6) | 31 (13) | 55 |
| Total | 249 | 246 | 495 |
|
| |||
| Histological Grade | |||
| 1 | 2 (0.9) | 4 (1.9) | 6 |
| 2 | 32 (14) | 52 (25) | 84 |
| 3 | 180 (79) | 128 (61) | 308 |
| Unknown | 14 (6.1) | 27 (13) | 41 |
| Total | 228 | 211 | 439 |
|
| |||
| Mean tumor size (cm) | 1.12 | 1.3 | |
a
Ductal carcinoma in situ