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. 2017 Apr 5;10(2):39. doi: 10.3390/ph10020039

Table 1.

Expression and roles of TRPM7 channels in various human malignancies.

Cancer Expression Functional roles of TRPM7 References
Pancreatic adenocarcinoma
  • -

    Increased in human pancreatic adenocarcinoma tissues and cell lines.

  • -

    Increased in chronic pancreatitis, pancreatic intra-epithelial neoplasms

  • -

    Required for cellular proliferation and cell cycle progression involving Mg2+.

  • -

    Required for preventing replicative senescence.

  • -

    Required for cell migration involving Mg2+.

  • -

    Required for cell invasion.

[9,27,28,29,30,31]
Breast carcinoma
  • -

    Over-expression in human breast carcinoma tissues and cell lines

  • -

    Increased expression in infiltrating ductal carcinoma with microcalcifications

  • -

    Somatic mutation T720S (Thr→Ser) in a breast infiltrating ductal carcinoma

  • -

    Required for cancer cell proliferation in vitro.

  • -

    Required for cancer cell migration in vitro and tumor metastasis in a mouse xenograft model.

  • Waixenicin A, TRPM7 blocker, inhibits growth and survival of breast cancer cells MCF-7.

  • -

    TRPM7 involved in estrogen receptor-negative metastatic breast cancer cells migration through kinase domain.

  • -

    Involved in ginsenoside Rd-induced apoptosis in cells.

  • -

    Involved in epithelial mesenchymal transition.

  • -

    TRPM7 mediates migration and invasion of breast cancer cells (MDA-MB-435) involving phosphorylation of Src and MAPK.

[32,33,34,35,36,37,38,39,40]
Gastric carcinoma
  • -

    Expressed in human gastric adenocarcinoma cell lines (AGS, MKN-1, MKN-45, SNU-1, SNU-484)

  • -

    Somatic mutation M830V (Met→Val) in gastric adenocarcinoma

  • -

    Required for cell survival involving Mg2+.

  • -

    Waixenicin A, TRPM7 blocker, inhibits growth and survival of gastric cancer cells AGS.

  • -

    Involved in ginsenoside Rd-induced apoptosis AGS cells.

[37,38,40,41,42,43]
Head and neck Carcinoma
  • -

    Expressed in FaDu cells and SCC-25 cells.

  • -

    High expression in 5-8F cells, low expression in 6-10B cells

  • -

    Required for cell growth and proliferation.

  • -

    Required for migration of nasopharyngeal carcinoma cells (5-8F and 6-10B).

  • -

    Proliferation of FaDu hypopharyngeal squamous cells (FaDu) inhibited by midazolam that targets TRPM7.

[44,45,46]
Retinoblastoma
  • -

    Existence in 5-8F cells

  • -

    Required for cell proliferation.

  • -

    Required for 5-8F cell migration.

[47]
Melanoma
  • -

    Expressed in cell lines

  • -

    Not reported.

[48,49]
Lung carcinoma
  • -

    Expressed in A549 cells

  • -

    Required for migration of A549 cells.

[50]
Erythroleukemia
  • -

    TRPM7-like currents in cell lines

  • -

    Not reported.

[51]
Colon cancer
  • -

    TRPM7 (Thr1482Ile) polymorphism

  • -

    TRPM7 (Thr1482Ile) polymorphism associated with elevated risk of both adenomatous and hyperplastic polyps.

  • -

    Individuals with TRPM7 (Thr1482Ile) polymorphism with a high Ca:Mg ratio intake in diet at a relatively high risk of developing adenoma and hyperplastic polyps.

[52]
Leukemia
  • -

    Not reported

  • -

    Waixenicin inhibits T cell leukemia (Jurkat T lymphocytes) and rat basophilic leukemia cells (RBL1) through blocking TRPM7 channel activity.

[53]
Neuroblastoma
  • -

    Not reported

  • -

    In mouse neuroblastoma cells (N1E-115), TRPM7 promotes formation of Ca2+ sparking and invadosome by affecting actomyosin contractility independent from Ca2+ influx.

  • -

    In vivo and in vitro studies using N1E-115 cells, TRPM7 promotes tumor metastasis in a mouse xenograft model and cell migration in Boyden chamber.

[54,55]
Ovarian carcinoma
  • -

    Somatic mutation S406C (Ser→Cys) in ovarian serous carcinoma

  • -

    Not reported.

[40]
Prostate cancer
  • -

    Expressed in human prostate cancer cell line DU145

  • -

    Increased Ca2+ to Mg2+ ratio in prostate cancer cells enhances TRPM7-mediated currents and promotes cellular entry of Ca2+, leading to increase in cell proliferation.

[56]
Glioblastoma
  • -

    Over-expressed in human glioblastoma cell line U87

  • -

    Carvacrol inhibits TRPM7 and suppresses glioblastoma cell proliferation, migration, and invasion

  • -

    Xylokeletal B inhibits TRPM7 and suppresses glioblastoma cell proliferation and migration through PI3K/Akt and MEK/ERK signaling

  • -

    Midazolam inhibits TRPM7-mediated current and suppresess TRPM7 expression, and induces cell cycle arrest and impairs proliferation

[57,58,59]