Table 1.

Thermodynamic parameters for the interaction of R8 with heparin or egg phosphatidylcholine (EPC)/egg phosphatidylglycerol (EPG) large unilamellar vesicles (LUVs) obtained from isothermal titration calorimetry (ITC).

	Binding Stoichiometry (n)	K (M−1)	ΔG° (kcal/mol)	ΔH° (kcal/mol)	TΔS° (kcal/mol)
Heparin	R8/heparin = 11 ± 1.1	(1.3 ± 0.22) × 108	−10.9 ± 0.10	−9.6 ± 0.53	1.3 ± 0.54
EPC/EPG LUV	lipid/R8 = 100 ± 10	(1.5 ± 0.25) × 106	−8.4 ± 0.10	−6.3 ± 0.10	2.1 ± 0.10

For original ITC data, see Figure 4 and Figure 5.